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UConn Health University of Connecticut-Wesleyan University Stem Cell Core

Distribution of hESC/iPSC Lines

We have derived our own hESC lines and also banked hESC lines from WiCell, Harvard Stem Cell Institute, and ES Cell International. We have also been deriving iPSC lines from patient or normal human samples such as skin fibroblasts, cord blood or peripheral blood mononucleocytes using retroviral, lentiviral (transgene removable), episomal, and mRNA-based methods to deliver reprogramming factors. iPSC lines derived via episomal or mRNA transfection are considered integration-free.

These hESC/iPSC lines (see updated tables below) are available as frozen vials. However, live culture may be available for some of the lines. Please first contact us at ucscicore@uchc.edu as to the time for preparation and shipment of requested cell line(s). To order the cell lines, please follow the instructions below.

For internal users of UConn Health and UConn Storrs:
Please order the lines using your research store account. Following documents must be ready before your order, especially if it is the first time for you to request.

  1. Using stem cell lines requires Stem Cell Research Oversight (SCRO) approval. SCRO forms and instructions are available at the UConn SCRO’s website.
  2. MTAs for hESC lines:
    For hESC lines derived at UConn Health, an internal MTA will be required. For hESC lines owned by WiCell, an SLA with WiCell is required. The SLA will need institutional signature from ORSP and an executed agreement signed by an officer of WiCell. MTAs for hiPSC lines derived at the UCSCC vary among agreements required for the hiPSC lines. Please contact Dr. Gregory Gallo, director of Life Sciences Licensing of UConn, at ggallo@uchc.edu.

For external users from other universities or institutions:
For hESC and hiPSC lines derived at the UCSCC, a MTA with UConn is required. Please contact Dr. Gregory Gallo at ggallo@uchc.edu. For hESC and hiPSC lines derived elsewhere, please contact the owners’ institutions listed in the tables.

hESC Bank

Cell Line Name

NIH Registration Number

Reference

For MTA, Contact

CT1

0068

Lin, et al., 2010

UCSCC

CT2

0069

Lin, et al., 2010

UCSCC

CT3

0070

Lin, et al., 2010

UCSCC

CT4

0071

Lin, et al., 2010

UCSCC

H1

0043

Thomson, et al., 1998

WiCell Research Inst.

H7

0061

Thomson, et al., 1998

WiCell Research Inst.

H9

0062

Thomson, et al., 1998

WiCell Research Inst.

H13

0063

Thomson, et al., 1998

WiCell Research Inst.

H14

0064

Thomson, et al., 1998

WiCell Research Inst.

 

iPSC Bank

Cell Line Name

Source Cells

Method/Factors

Reference(s)

For MTA, Contact

HDFa-YK27

Human dermal fibroblast line HDFa

Retroviral/OCT4, SOX2, KLF4, & C-MYC

Martins-Taylor, et al., 2011

UCSCC

IMR90-TZ1

Human fetal lung fibroblast line IMR90

Lentiviral/OCT4, SOX2, NANOG, LIN28, KLF4, & C-MYC

Zeng, et al., 2010

UCSCC

ICF-iPS

Skin fibroblasts from an ICF patient

Lentiviral/OCT4, SOX2, NANOG, LIN28, KLF4, & C-MYC

Martins-Taylor, et al., 2011 & Martins-Taylor, et al., 2012

UCSCC

RX47I-RIP1

Human neonatal foreskin fibroblast line BJ

mRNA/OCT4, SOX2, KLF4, C-MYC, & LIN28

Warren, et al., 2010

UCSCC

CB-iPS-lenti

 

Human cord blood MNC

stemcca - lentiviral

Somerset al., 2010

UCSCC

CB-iPS-epi

Human cord blood MNC

Episomal/ OCT4, SOX2, KLF4, L-MYC, LIN28, & P53-shRNA

Chou, et al., 2011 & Okita, et al., 2011

UCSCC

PB-iPS

Human peripheral blood MNC

Episomal/ OCT4, SOX2, KLF4, L-MYC, LIN28, & P53-shRNA